Greenwood is a city in Greenwood County, South Carolina, in the United States. It is located within the lower Piedmont region of Upstate South Carolina. Nicknamed "The Emerald City", it is the county seat of Greenwood County.

Located at 34.1885, -82.1605 the the city has a total area of 13.7 square miles (35.5 km²), of which, 13.7 square miles (35.5 km²) of it is land and 0.07% is water.

As of the 2000 census, there were 22,071 people, 8,496 households, and 5,174 families residing in the city. The population density was 1,612.1 people per square mile (622.5/km²). There were 9,373 housing units at an average density of 684.6/sq mi (264.3/km²). The racial makeup of the city was 50.10% White, 45.51% African American, 0.19% Native American, 0.87% Asian, 0.07% Pacific Islander, 2.41% from other races, and 0.85% from two or more races. Hispanic or Latino of any race were 6.52% of the population.

There were 8,496 households out of which 28.6% had children under the age of 18 living with them, 34.5% were married couples living together, 21.0% had a female householder with no husband present, and 39.1% were non-families. 32.4% of all households were made up of individuals and 12.9% had someone living alone who was 65 years of age or older. The average household size was 2.41 and the average family size was 3.05.

In the city the population was spread out with 24.7% under the age of 18, 15.2% from 18 to 24, 27.3% from 25 to 44, 17.6% from 45 to 64, and 15.2% who were 65 years of age or older. The median age was 32 years. For every 100 females there were 86.6 males. For every 100 females age 18 and over, there were 82.5 males.

The median income for a household in the city was $26,284, and the median income for a family was $32,573. Males had a median income of $26,477 versus $21,476 for females. The per capita income for the city was $14,347. About 18.1% of families and 25.0% of the population were below the poverty line, including 34.4% of those under age 18 and 18.0% of those age 65 or over.